How Does CBD Work With The Human Body?

Explaining the interaction between CBD and the endocannabinoid system.

Our bodies are designed with a biological system made up of
endocannabinoids called the endocannabinoid system. Endocannabinoids are
internal lipid-based neurotransmitters that have the ability to combine
themselves with cannabinoid receptors located throughout our body. The
endocannabinoid system plays a crucial role in helping regulate an array
of physiological and cognitive processes, which include:

  • Memory
  • Mood
  • Pregnancy
  • Fertility
  • Appetite
  • Prenatal development
  • Postnatal development

These are not the only functions that the endocannabinoid system plays a
role in. The system also is involved in exercise too. Anytime an
individual engages in voluntary physical exercise, the endocannabinoid
system goes to work. The system helps in release of euphoria, while
having a controlling element of our locomotor activity. It even has an
impact on your motivational salience for rewards, which is our internal
meter in our body that decides how much energy and sacrifice you are
willing to put into a goal you are trying to achieve.

Receptors of the endocannabinoid system: CB1, CB2 and 2-AG

In the endocannabinoid system, there are two primary receptors. These
receptors are called CB1 and CB2. The receptors found in CB1 are
generally located throughout the brain, nervous system, peripheral
organs, intestines and tissues. These receptors are the main target for
the endocannabinoid-binding molecule called a ligand, as well as
anandamide (fatty acid neuro-transmitter), THC.

The CB2 receptor has a different set of responsibilities. These
receptors are found mostly in white blood cells, tonsils and the spleen.
They play an important function in the regulation of cytokine release.

There is one other main endocannabinoid that contributes to the
endocannabinoid system. This is the 2-AG. This endocannabinoid is active
in the CB1 and the CB2 and has its own mimetic phytocannabinoid, which
is CBD. The 2-AG and CBD play an important role in the regulation of the
immune system, managing discomfort and supporting in immune system

How CBD interacts with these receptors

CBD has an interesting way of interacting with out bodies. One would
think that the interaction is direct, while in fact it is an indirect
interaction. It acts upon the CB1 and CB2 receptors, but does not bind
with these receptors directly. Instead these indirect actions toward the
receptors activate the TRPV1 receptors. These receptors are responsible
for regulating body temperature, giving an individual the perception of
discomfort and swelling. Not only are these receptors interacted with,
but CBD also has an impact on amount of anandamide that is produced in
your body. Anandamide is the molecule in your body that contains a part
in neural generation of feelings we associate with pleasure and
motivation. This molecule is often referred to as the bliss molecule for
the outputs it puts into our body making us feel these positive feelings.

CBD stimulates the endocannabinoid system, which therefore helps with
homeostasis in the body, decreasing swelling and works to reduce
discomforts. Some of the benefits that CBD provides when it interacts
with the endocannabinoid system are:

  • Helping control IBS
  • Aiding in decreasing withdrawal symptoms from substance abuse
  • Improves concentration
  • Decreasing anxious feelings
  • Promotes sense of calmness
  • Reducing acne
  • Fights swelling
  • Combats bacterial infections
  • Reducing nausea

These are just a few of the mass amount of benefits your body receives
when CBD interacts with your bodies endocannabinoid system. When CBD
interacts with the CB1 receptors in our bodies it aids in:

  • Promoting a sense of calmness
  • Maintaining normal blood pressure
  • Reducing anxious feelings
  • Decreasing fear and paranoia
  • Diminishing intestinal swelling

Similar to the array of benefits CBD does for your body as a whole,
there is a list of the benefits it provides when interacting with your
CB1 receptors, too. CBD has a whole new set of roles it works in when
interacting with the CB2 receptors. These are:

  • Promoting skin health
  • Fighting malignant cell growth
  • Promoting good bone health
  • Alleviated discomforts
  • Aiding in kidney function CBD will change the way you feel

Although our body produces endocannabinoids already, the production of
these can be impaired by things we do to our body on a daily basis. An
outside source of CBD can help aid our endocannabinoid system in
returning to full function or even working above full functionality, and
lead to an all-around healthier and more fulfilled lifestyle.